Graduate School Department /Course /Field Interdisciplinary Environment/Molecular Studies on Chemical and Biological Environments/Environmental Molecular Life Science
Undergraduate School
Other Affiliation Radiation Biology Center
Email jkobayashi at house.rbc.kyoto-u.ac.jp
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Message to the prospective students

<To prospective students who hope to join My laboratory>
Our laboratory focus on biological response to genotoxic damages by ionizing radiation, ROS, UV or other environmental stresses using radiation hyper-sensitive disorders. We are also studying biological effect by low dose irradiation, which is currently interesting for most peoples in Japan.
If you are interested in such research area, please join in our lab as a graduate school student. The MEXT Scholarship candidates after passing primary screening are acceptable for my lab as PhD students. So far, my lab is accepting two students with that system.
Research areas Radiation Biology, Cell Biology
Keywords radiation, DNA damage, DNA repair, cell cycle, oxidative stress, genetic variation
Themes In oreder to clarify radiation-induced DNA damage response and mechanism of genomic stability mentenance, I am focusing on radiation-hypersensitive disorders and responsible genes, and studying following themes.
1. Investigation of radiation-hypersensitive disorders and role of responsible genes in DNA damage responses.
2. Role of oxidative stress (ROS) in biological effects to low dose rate irradiation.
3. Relationship between DNA repair capacity and genetic variation in primates.
Major publications Saito Y, Zhou H, Kobayashi J. Chromatin modification and NBS1: their relationship in DNA double-strand break repair. Genes Genet Syst. 90, 195-208, 2016.
Su F, Mukherjee S, Yang Y, Mori E, Bhattacharya S, Kobayashi J, Yannone SY, Chen DJ, Asaithamby A. Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress. Cell reports 9, 1387-1401, 2014.
Yoshiyama KO, Kobayashi J, Ogita N, Ueda M, Kimura S, Maki H, Umeda M. ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis. EMBO Rep, 14, 817-822, 2013.
Kobayashi J, Fujimoto H, Sato J, Hayashi I, Burma S, Matsuura S, Chen DJ, Komatsu K. Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway. PLoS One, 7, e49245 2012.
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K. NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol η-Dependent Translesion DNA Synthesis. Mol Cell, 43, 788-797, 2011.
Tauchi H, Kobayashi J, Morishima K, van Gent DC, Shiraishi T, Verkaik NS, vanHeems D, Ito E, Nakamura A, Sonoda E, Takata M, Takeda S, Matsuura S, Komatsu K. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature, 420, 93 - 98, 2002.
Professional societies/Research and synergic activities The Japanese Radiation Research Society
The Molecular Biology Society of Japan
Japanese Cancer Association
The Japanese Biochemical Society
Teaching Areas
  • Undergraduate courses
  • Graduate courses (Master's program) Genome Repair Dynamics
    Seminar in Environmental Molecular Life Science 1
    Seminar in Environmental Molecular Life Science 2
  • Graduate courses (Doctor's program) Special Studies on Interdisciplinary environment I
    Special Studies on Interdisciplinary environment II
    Advanced Seminar I in Environmental Molecular Life Sciences
    Advanced Seminar II in Environmental Molecular Life Sciences
  • Undergraduate courses open to all departments
Background <Education>
March 1988 Bachelor of Science (B.S.) Kwansei Gakuin University, Japan
March 1991 Master of Science (M.S.) Kwansei Gakuin University, Japan
March 1994 Doctor of Philosophy (Ph.D.) Hiroshima University, Japan

<Research and Professional experience>
Apr. 1994 - Sep. 1997 Postdoctoral, National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology, Japan
Oct. 1997 – Mar. 2005 Research associate, Faculty of Dentistry, Hiroshima University, Japan
Feb. 2002 – Apr. 2005 Instructor, Faculty of Dentistry, Hiroshima University, Japan
Apr. 2002 – Apr. 2005 Research associate, Graduate School of Biomedical Sciences, Hiroshima University, Japan
Oct. 2002 - Mar. 2004 Postdoctoral, Lawrence Berkeley National Laboratory, Berkeley, USA
May 2005 – Feb.2011 Assistant professor, Radiation Biology Center, Kyoto University, Japan
Mar. 2011 - Associate professor, Radiation Biology Center, Kyoto University, Japan

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