KOMATSU, Naoki Professor
Graduate School | Human and Environmental Studies/Materials Science |
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Undergraduate School | Materials Science (Division of Natural Sciences) |
Other Affiliation | |
komatsu.naoki.7w(_at_)kyoto-u.ac.jp | |
Personal Page | Website |

Research areas | Organic Chemistry, Materials Chemistry, Supramolecular Chemistry, Nanoscience, Nanomedicine |
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Keywords | carbon nanotubes, graphene, nanodiamond, nanoparticles, drug delivery, imaging probe, structural separation, chemical functionalization |
Themes | The concept of our research is to apply methodology in organic chemistry to nanomaterials including carbon nanotubes (CNTs), nanodiamond (ND), graphene and various kind of nanoparticles. Our work is classified into the following two subjects; 1) structural separation of CNTs and grapheme through host-guest chemistry, and 2) chemical functionalization of ND, CNTs, graphene, and metal oxide nanoperticles, and their biomedical applications. In the former, we developed optical resolution of CNTs by tweezer- and caliper-shaped host molecules named "nanotweezers" and "nanocalipers", respectively. In the latter, the nanomaterials are well-dispersed in a physiological environment by coating with polyglycerol (PG). We further functionalize the PG-coated nano particles with targeting peptide and/or anti-cancer drug for drug delivery. |
Major publications | "Optically Active Single-Walled Carbon Nanotubes", Nature Nanotechnology, 2, 361-365 (2007) Polyglycerol Grafting Shields Nanoparticle from Protein Corona Formation to Avoid Macrophage Uptake" ACS Nano, 14, 7216-7226 (2020) "Chemical functionalization of nanodiamonds: opportunities and challenges ahead" Angew. Chem. Int. Ed., 58 (50), 17918-17929 (2019) "Direct Fabrication of the Graphene-Based Composite for Cancer Phototherapy through Graphite Exfoliation with a Photosensitizer" ACS Appl. Mater. Interfaces, 7 (42), 23402-23406 (2015) "Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting Peptide, and Acid-Responsive Antitumor Drug" Adv. Funct. Mater., 24, 5348-5357 (2014) "Simultaneous Discrimination of Diameter, Handedness, and Metallicity of Single-Walled Carbon Nanotubes with Chiral Diporphyrin Nanocalipers", J. Am. Chem. Soc., 135, 4805-4814 (2013) "Hyperbranched Polyglycerol-Grafted Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization, Functionalization, Size Separation, Magnetic Properties, and Biological Applications" Adv. Funct. Mater., 22, 5107-5117 (2012). "Chromatographic Separation of Highly Soluble Diamond Nanoparticles Prepared by Polyglycerol Grafting" Angew. Chem. Int. Ed., 50, 1388-1392 (2011) |
Professional societies/Research and synergic activities | Chemical Society of Japan, American Chemical Society, The Fullerene, Nanotubes, and Graphene Research Society, The Carbon Society of Japan, New Diamond Forum, Japanese Society for Molecular Imaging 2012, 2014 Symposium organizer in E-MRS spring meeting |
Teaching Areas |
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Background | 2015 Professor in Kyoto University 2003 Associate Professor in Shiga University of Medical Science (SUMS) 1997~1998 Postdoctoral Researcher in Florida State University 1994 Assistant Professor in Kyoto University 1993 PhD from Kyoto University 1993 Assistant Professor in Okayama University 1988 MSc from Kyoto University |